Ababio ASHONG^{* *}Correspondence: Ababio ASHONG, Department of Nutrition, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, Email:

Received: 21-Aug-2024, Manuscript No. CNHD-24-151910; Editor assigned: 23-Aug-2024, Pre QC No. CNHD-24-151910 (PQ); Reviewed: 06-Sep-2024, QC No. CNHD-24-151910; Revised: 13-Sep-2024, Manuscript No. CNHD-24-151910 (R); Published: 20-Sep-2024, DOI: 10.12873/0211-6057.44.03.230

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Description

Cancer remains one of the most prevalent and deadly diseases worldwide, driving researchers to examine various preventive and therapeutic strategies. Among the growing fields of interest, phytochemicals have emerged as promising compounds in cancer prevention and treatment. These naturally occurring compounds, found in fruits, vegetables, herbs, and other plant-based foods, have demonstrated potential in reducing the risk of cancer and supporting conventional treatment methods.

Phytochemicals in cancer prevention

Phytochemicals are bioactive compounds that offer a wide range of health benefits, primarily due to their antioxidant, anti-inflammatory, and anti-carcinogenic properties. Some of the most studied phytochemicals include flavonoids, carotenoids, polyphenols, and glucosinolates, each contributing to cancer prevention through various mechanisms. One of the primary ways phytochemicals help in cancer prevention is by acting as antioxidants. Free radicals, which are highly reactive molecules, can damage cells and DNA, leading to mutations that contribute to cancer development. Phytochemicals like flavonoids and carotenoids, abundant in colorful fruits and vegetables, neutralize free radicals and reduce oxidative stress, thus protecting cells from DNA damage [1-3].

Additionally, phytochemicals possess anti-inflammatory properties that play an important role in cancer prevention.

Chronic inflammation is a well-established risk factor for several types of cancer, particularly colorectal and liver cancers. Phytochemicals such as curcumin (found in turmeric), resveratrol (found in grapes), and quercetin (found in apples and onions) modulate inflammatory pathways, inhibiting the release of pro-inflammatory cytokines and enzymes that promote cancer cell growth and spread. By regulating inflammation, these compounds help prevent the initiation and progression of cancer [4-7].

Another key mechanism is the regulation of cell cycle progression and apoptosis (programmed cell death). Phytochemicals like sulforaphane, found in cruciferous vegetables such as broccoli, stimulate the body’s defense mechanisms to detoxify carcinogens and prevent abnormal cell proliferation. Sulforaphane and other phytochemicals can also trigger apoptosis in damaged or precancerous cells, preventing the growth of tumors.

Phytochemicals in cancer treatment

In addition to their preventive role, phytochemicals have been shown to enhance the effectiveness of conventional cancer treatments, such as chemotherapy and radiation therapy. Some phytochemicals can sensitize cancer cells to these treatments, making them more effective in destroying cancerous cells. For example, curcumin, a compound found in turmeric, has gained attention for its potential to enhance the effects of chemotherapy. Curcumin not only exhibits anti-cancer properties on its own but also increases the sensitivity of cancer cells to chemotherapy drugs like paclitaxel and cisplatin. By interfering with the molecular pathways that protect cancer cells, curcumin can make the cells more vulnerable to treatment, potentially improving patient outcomes [8-10].

Similarly, resveratrol has shown promise in combination with radiation therapy. Studies have indicated that resveratrol can enhance the ability of radiation to target and kill cancer cells while reducing the side effects of radiation on healthy tissues. This synergy between phytochemicals and conventional treatments holds the potential for more effective and less toxic cancer therapies.

Phytochemicals also support cancer treatment by improving the overall well-being of patients. Many cancer treatments, particularly chemotherapy, are associated with severe side effects, such as fatigue, nausea, and loss of appetite. Phytochemicals like ginger, known for its anti-nausea properties, and green tea polyphenols, which boost the immune system, can help alleviate some of these side effects. This supportive role is vital in improving the quality of life for cancer patients undergoing aggressive treatments. Moreover, some phytochemicals possess the ability to inhibit the metastasis (spread) of cancer cells. For instance, Epigallocatechin Gallate (EGCG), a polyphenol found in green tea, has been shown to suppress the spread of breast cancer cells to other parts of the body. This inhibition of metastasis can significantly improve the prognosis and survival rates of patients with metastatic cancers.

Phytochemicals offer immense promise in both cancer prevention and treatment. Through their antioxidant, anti-inflammatory, and anticancer properties, they play an important role in reducing cancer risk by protecting cells from DNA damage, controlling inflammation, and inducing apoptosis in abnormal cells. Furthermore, phytochemicals enhance the efficacy of conventional cancer treatments like chemotherapy and radiation while alleviating their side effects, offering a complete approach to cancer care. As research continues to evolve, the integration of phytochemicals into cancer prevention strategies and treatment protocols could revolutionize cancer care, providing a safer, more effective way to fight this global health challenge. By incorporating a diet rich in plant-based foods, individuals can control the power of phytochemicals to not only reduce their cancer risk but also support their bodies in the fight against the disease.

References

1. Ito H, Nakasuga K, Ohshima A, Maruyama T, Kaji Y, Harada M, et al. Detection of cardiovascular risk factors by indices of obesity obtained from anthropometry and dual-energy X-ray absorptiometry in Japanese individuals. Int J Obes. 2003; 27(2): 232–237.

   [Crossref] [Google Scholar] [Indexed]

2. Naja F, Hamadeh R. Nutrition amid the COVID-19 pandemic: A multi-level framework for action. Eur J Clin Nutr. 2020; 74(8): 1117–1121.

   [Crossref] [Google Scholar] [Indexed]

3. Brooks SK, Webster RK, Smith LE, Woodland L, Wessely S, Greenberg N, et al. The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Lancet. 2020; 395(10227): 912–20.

   [Crossref] [Google Scholar] [Indexed]

4. Tang W, Hu T, Hu B, Jin C, Wang G, Xie C, et al. Prevalence and correlates of PTSD and depressive symptoms one month after the outbreak of the COVID-19 epidemic in a sample of home-quarantined Chinese university students. J Affect Disord. 2020; 274: 1–7.

   [Crossref] [Google Scholar] [Indexed]

5. Korkut GD. Evaluation of dietary habits and physical activity status of first and emergency aid students in COVID-19 pandemic. J Paramed Emerg Heal. 2020; 1(1): 1–15.
6. Cesur F, Cengiz H, Vural H. The effect of walnut consumption on small dense low-density lipoprotein and other serum lipid parameters in healthy volunteers. Turkiye Klin J Heal Sci. 2022; 7(1): 11–8.

   [Google Scholar]

7. Bousquet J, Anto JM, Iaccarino G, Czarlewski W, Haahtela T, Anto A, et al. Is diet partly responsible for differences in COVID-19 death rates between and within countries? Clin Transl Allergy. 2020; 10: 16

   [Crossref] [Google Scholar] [Indexed]

8. Sandalcı B, Uyaroğlu OA, Sain Güven G. The role, significance and recommendations of chronic diseases in COVID-19. Flora J Infect Dis Clin Microbiol. 2020; 25(2): 132–138.

   [Google Scholar]

9. Kamarlı AH, Seremet KN, Karaçil Ermumcu MS. Increased use of dietary supplements and herbal products in adults during COVID-19: A cross-sectional study. Turkiye Klin J Heal Sci. 2022; 7(1): 29–35.

   [Google Scholar]

10. Balanzá-Martínez V, Kapczinski F, de Azevedo CT, Atienza-Carbonell B, Rosa AR, Mota JC, et al. The assessment of lifestyle changes during the COVID-19 pandemic using a multidimensional scale. Rev Psiquiatr Salud Ment 2021; 14(1): 16–26.

    [Crossref] [Google Scholar] [Indexed]